PROMETHAZINE CODEINE COUGH SYRUP
About promethazine / codeine
Promethazine / codeine is a combination of two medications: promethazine and codeine. Promethazine is a phenothiazine medication that blocks the signals in your brain and body causing you to experience cold and allergy symptoms like a runny nose and sneezing. Codeine is an opioid medication that works in your brain to lessen your urge to cough
Uses of codeine syrup
- Respiratory symptoms caused by allergies or the common cold, including cough, runny nose, and sneezing
How to dose on codeine
Adults over 18 years old: The typical dose is 5 mL (1 teaspoonful) by mouth every 4 to 6 hours as needed. Do not take more than 30 mL (6 teaspoonfuls) in a day.
Promethazine / codeine is not recommended for use in children under 18 years old
Things to know before taking codeine syrup
You should not use Promethazine with Codeine if you are allergic to codeine or promethazine, or if you have:
- asthma or severe breathing problems;
- a stomach or bowel obstruction (including paralytic ileus)
- narrow-angle glaucoma; or
- if you are unable to urinate.
Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Possible side effects of codeine and promethazine
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Stop using this medicine and call your doctor at once if you have:
- noisy breathing, sighing, shallow breathing;
- extreme drowsiness, confusion, feeling weak or limp;
- uncontrolled muscle movements in your face, neck, arms, or legs;
- a light-headed feeling, like you might pass out;
- a seizure;
- adrenal gland problems –nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness; or
- severe nervous system reaction –very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
Common side effects may include:
- dry mouth, nausea, vomiting, constipation;
- confusion, dizziness, headache;
- drowsiness, lack of energy;
- tremors, coordination problems;
- feeling anxious, restless, nervous, or irritable;
- urination problems;
- sweating; or
- shortness of breath.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088