Ketamine Nasal Spray

How Does Ketamine Nasal Spray Work?

Unlike traditional antidepressants that target serotonin and dopamine, ketamine nasal spray affects the glutamate system. This mechanism helps create new neural connections, which can improve mood and cognitive function. By modulating glutamate, ketamine nasal spray works differently than nasal antidepressants that typically target serotonin. It is often used as a last resort for treatment-resistant depression and severe anxiety disorders, providing rapid relief in comparison to SSRIs and SNRIs.

The effectiveness of intranasal ketamine varies, but many patients report improvements within hours of administration. This rapid onset is one of the reasons why ketamine nasal spray for depression has gained popularity. The ability to provide quick relief makes it a valuable option for managing acute depressive episodes.

How Long Does Ketamine Nasal Spray Last & Take to Work?

One of the most commonly asked questions is how long does ketamine nasal spray last? The effects of nasal ketamine can be felt within 30 minutes to 2 hours, depending on the individual and dosage. Typically, relief from depressive symptoms can last anywhere from a few days to a week. This duration can vary significantly based on factors such as dosage, individual response, and frequency of use.

• How long does ketamine nasal spray take to work? Most patients feel relief within hours, making it significantly faster than SSRIs, which can take weeks to show effects.
• Unlike traditional antidepressants, ketamine nasal spray may require weekly or biweekly doses rather than daily use, which can be more convenient for some patients.
• The rapid onset of action makes ketamine nasal spray particularly useful for managing severe depressive episodes where immediate relief is needed.

Ketamine Nasal Spray Dosage & How to Use It

The ketamine nasal spray dosage depends on whether a patient is using Spravato (esketamine nasal spray) or a compounded ketamine nasal spray.

• Esketamine nasal spray dosage: Typically 56-84 mg per session, administered under medical supervision to ensure safety and efficacy.
• Compounded ketamine nasal spray dosage: Varies depending on formulation and physician recommendations. It is crucial to follow the prescribed dosage carefully to avoid overuse and potential side effects.
• Requires careful titration to ensure the right balance between therapeutic benefits and minimizing side effects.

Due to the potential risks associated with ketamine use, nasal ketamine spray should always be taken under professional guidance. This ensures that patients receive the correct dosage and are monitored for any adverse reactions.